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pentobarbital will decrease the level or effect of phenytoin by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Check.pentobarbital will lower the extent or effect of budesonide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.Watch Intently (one)pentobarbital will reduce the extent or effect of bupren